Professor XIA, Jiang（夏江教授） - Department of Chemistry, The Chinese University of Hong Kong

Professor

Room 360 Science Centre

(852) 3943 6165

(852) 2603 5057

jiangxia@cuhk.edu.hk

Education

1999	B.Sc.	Nanjing University
2002	M.S.	Nanjing University
2006	Ph.D.	Stanford University

Position

Since 2021.8	Professor, Department of Chemistry, Professor (by courtesy), School of Life Sciences, The Chinese University of Hong Kong
2015-2021	Associate Professor (by courtesy), School of Life Sciences, The Chinese University of Hong Kong
2015-2021	Associate Professor, Department of Chemistry, The Chinese University of Hong Kong
2009-2014	Assistant Professor, The Chinese University of Hong Kong
2007-2008	Research Associate, Howard Hughes Medical Institute
2007-2008	Postdoctoral scholar, California Institute of Technology

Research Interests

Chemical and synthetic biology

We are interested in the chemistry, biology, and engineering of proteins.

Site-selective protein reactions
Residue-specific (cysteine, tyrosine, and lysine) reactions of proteins, enzymes, and antibodies in vitro and in cells

Multienzyme complexes
Multienzyme complexes, synthetic metabolon, and synthetic organelles; regulation of metabolic flux in prokaryotic and eukaryotic cells for better biosynthesis of carotenoids, artemisinin, cannabinoids, or amorphadiene, in vitro and in cells

Regenerative medicine
Engineering exosomes, extracellular vesicles, and cells for targeted therapy of cartilage and skin regeneration, peptides or enzymes against bacterial infection, and cancer therapies in cells and in vivo

Recent Publications

For the complete publication list, click here

1	Yuan, D.†; Zhang, Y.†; Lim, K. H.; Leung, S. K. P.; Yang, X.; Liang, Y.; Lau, W. C. Y.; Chow, K. T.; Xia, J.** Site-Selective Lysine Acetylation of Human Immunoglobulin G for Immunoliposomes and Bispecific Antibody Complexes. J. Am. Chem. Soc. 2022, Accepted. (†, equal contribution)
2	Wang, Y.†; Liu, M.†; Wei, Q.; Wu, W.; He, Y.; Gao, J.; Zhou, R.; Jiang, L.; Qu, J.; Xia, J.* Phase-Separated Multienzyme Compartmentalization for Terpene Biosynthesis in a Prokaryote Angew. Chem. Int. Ed. 2022, e202203909.
3	Wei, Q.†; Wang, Y.†; Liu, Z.†; Liu, M.; Cao, S.; Jiang, H.; Xia, J.* Multienzyme Assembly on Caveolar Membranes In Cellulo ACS Catalysis 2022, 12, 8372-8379. (†, equal contribution)
4	Liang, Y.; Xu, X.; Xu, L.; Ouyang, K.; Zhang, H.; Duan, L.; Xia, J.* Chondrocyte-Specific Genome Editing Enabled by Hybrid Exosomes for Osteoarthritis Treatment Theranostics 2022, 12, 4866-4878.
5	Liang, Y.†; Iqbal, Z.†; Lu, J.; Wang, J.; Zhang, H.; Chen, X.; Duan, L.; Xia, J. Cell-Derived Nanovesicle-Mediated Drug Delivery to the Brain: Principles and Strategies for Vesicle Engineering. Molecular Therapy 2022 Accepted.
6	So, W. H.†; Bao, Y.†; Chen, X.; Xia, J.* On-Resin Ugi Reaction for C-Terminally Modified and Head-to-Tail Cyclized Antibacterial Peptides Organic Letters 2021, 23, 8277-8281. (†, equal contribution)
7	Duan, L.; Ouyang, K.; Wang, J.; Xu, L.; Xu, X.; Wen, C.; Xie, Y.; Liang, Y.; Xia, J. Exosomes as Targeted Delivery Platform of CRISPR/Cas9 for Therapeutic Genome Editing ChemBioChem 2021, 22, 3360-3368.
8	Chen, X.; Liu, M.; Zhang, P.; Xu, M.; Yuan, W.; Bian, L.; Liu, Y.; Xia, J.; Leung, S. S. Y. Phage-Derived Depolymerase as an Antibiotic Adjuvant Against Multidrug-Resistant Acinetobacter Baumannii Frontiers in Microbiology, 2022, 13, 845500.
9	Chen, X.; Liu, M.; Zhang, P.; Leung, S. S. Y.; Xia, J. Membrane-Permeable Antibacterial Enzyme against Multidrug-Resistant Acinetobacter baumannii ACS Infectious Diseases, 2021, 7, 2192–2204.
10	Wang, C.; Hong, T.; Cui, P.; Wang, J.; Xia, J. Antimicrobial peptides towards clinical application: delivery and formulation Advanced Drug Delivery Review, 2021, 175, 113818.
11	Liang, Y.; Duan, L.; Lu, J.; Xia, J.* Engineering exosomes for targeted drug delivery Theranostics 2021, 11, 3183-3195.
12	Qiu, J.; Nie, Y.; Zhao, Y.; Zhang, Y.; Li, L.; Wang, R.; Wang, M.; Chen, S.; Wang, J.; Li, Y.Q.; Xia, J.* Safeguarding intestine cells against enteropathogenic Escherichia coli by intracellular protein reaction, a preventive antibacterial mechanism Proc. Natl. Acad. Sci. U. S. A. 2020, 117, 5260-5268.
13	Xu, X.; Liang, Y.; Li, X.; Ouyang, K.; Wang, M.; Cao, T.; Li, W.; Liu, J.; Xiong, J.; Li, B.; Xia, J.; Wang, D.; Duan, L.* Exosome-Mediated Delivery of Kartogenin for Chondrogenesis of Synovial Fluid-Derived Mesenchymal Stem Cells and Cartilage Regeneration Biomaterials 2020, 269, 120539.
14	Liang, Y.; Xu, X.; Li, X.; Xiong, J.; Li, B.; Duan, L.; Wang, D.; Xia, J.* Chondrocyte-Targeted MicroRNA Delivery by Engineered Exosomes toward a Cell-Free Osteoarthritis Therapy ACS Appl. Mater. Interfaces 2020, 12, 36938–36947
15	Liu, M.; He, S.; Cheng, L.; Qu, J.; Xia, J.* Phase-separated multienzyme biosynthesis Biomacromolecules, 2020, 21, 2391-2399.
16	So, W. H.; Xia, J.* On-Resin Passerini Reaction towards C-Terminal Photocaged Peptides Organic Lett. 2020, 22, 214-218.
17	Wei, Q.; He, S.; Qu, J.; Xia, J.* “Synthetic Multienzyme Complexes Assembled on Virus-like Particles for Cascade Biosynthesis In Cellulo” Bioconjugate Chem. 2020, 31, 2413-2420.
18	Kang, W.; Ma, T.; Liu, M.; Qu, J.; Liu, Z.; Zhang, H.; Shi, B.; Fu, S.; Ma, J.; Lai, L.; He, S.; Qu, J.; Au, S. W-N.; Kang, B. H.; Lau, W. C. Y.; Deng, Z.; Xia, J., Liu, T.. Modular enzyme assembly for enhanced cascade biocatalysis and metabolic flux Nat. Commun. 2019, 10, 4248.
19	Liu, Z.; Cao, S.; Liu, M.; Kang, W.; Xia, J.* Self-Assembled Multi-Enzyme Nanostructures on Synthetic Protein Scaffolds ACS Nano 2019, 13, 11343-11352.
20	Qu, J., Cao, S., Wei, Q., Zhang, H., Wang, R., Kang, W., Ma, T., Zhang, L., Liu, T., Au, W-N. S., Sun, F., Xia, J.* Synthetic Multienzyme Complexes, Catalytic Nanomachineries for Cascade Biosynthesis In Vivo. ACS Nano 2019, 13, 9895-9906.

Recent Grants

1.	ITF TCFS, 1/8/2022 – 31/7/2024, PI Title: Engineering Exosomes for Tissue Regeneration and Osteoarthritis Treatment ITC GHP/074/20SZ: HK$1,350,000 Shenzhen Kaimao Biotechnology Co. Ltd.: HK$150,000 PH-ITF: PiH/283/22 HK$804,000 PH-ITF: PiH/284/22 HK$804,000
2.	RGC GRF 22/23, 14306222, 1/1/2023– 31/12/2025, HK$ 870,000, PI Title: Chemoenzymatic tyrosine reactions for covalent protein labeling and exosome tracking
3.	RGC GRF 21/22, 14304921, 1/1/2022 – 31/12/2024, HK$ 624,615, PI Title: Phase-separated multienzyme biosynthesis in vitro and in cellulo
4.	RGC GRF 20/21, 14304320, 1/1/2021 – 31/12/2023, HK$ 666,512, PI Title: Site-Specific Acetylation of Immunoglobulin G, for Covalent Construction of Therapeutic Antibody Conjugates
5.	Research Sustainability of Major RGC Funding Schemes (RSFS), 4930971, CUHK Faculty of Medicine. 3/6/2019 – 2/12/2020. HK$ 625,000. PI Title: Stem Cell-Based Chemical Biology Approach to Cartilage Repair
6.	ITF TCFS, 1/2/2020 – 31/1/2022, PI (total 3,931,244.81 HKD) Title: Efficient Enzymatic Production of Diacylglycerol ITC GHP/060/18GD: HK$ 1,620,000 Shenzhen WWHS Ltd.: HK$180,000 PH-ITF: PiH/395/19: HK$ 801,782.75 PH-ITF: PiH/396/19: HK$ 801,782.75 InP/459/19, ITC: HK$ 527,679.31 PH-ITF: PiH/321/20: HK$539,360 PH-ITF: InP/334/20: HK$ 299,961.29.
7.	NSFC/RGC 18/19, N_CUHK422/18, 1/1/2019-31/12/2022, HK$ 1,120,056, PI Title: Hybrid Antimicrobial Peptide-Nylon-3 Polymers to Treat Infection in the Brain
8.	Collaborative grant from industry, TJ1914536, 1/3/2020 – 28/2/2025, HK$ 1,500,000, PI Title: Recombinant collagen biomaterials Grant source: Jiangsu Unicollagen Biomedicine Co., Ltd.