Professor Jiang XIA(夏江教授)

Associate Professorppl---Jx

location Room 360 Science Centre
Phone No. (852) 3943 6165
Fax No. (852) 2603 5057









1999 B.Sc. Nanjing University
2002 M.S. Nanjing University
2006 Ph.D. Stanford University



Since 2015.4 Associate Professor (by courtesy), School of Life Sciences, The Chinese University of Hong Kong
Since 2014.12 Associate Professor, Department of Chemistry, The Chinese University of Hong Kong
2008.12-2014.12 Assistant Professor, The Chinese University of Hong Kong
2007-2008 Research Associate, Howard Hughes Medical Institute
2007-2008 Postdoctoral scholar, California Institute of Technology


Research Interests

Chemical biology, synthetic biology, and biomaterials

1. New protein reactions, and the functionalization of proteins and therapeutic antibodies
2. Synthetic metabolons and organelles based on protein assembly technologies for cascade biocatalysis
3. Protein-based biomaterials for anti-bacterial infection and tissue regeneration

Our work focuses on the reaction, assembly, and engineering of proteins for chemical biology, synthetic biology, and biomaterials applications. We have a focused interest in subcellular structures, such as organelles and protein coacervates, and their biocatalytic and biomedical applications.


Recent Publications

1  “Gelatinase-responsive release of antibacterial photodynamic peptide against Staphylococcus aureus”
Qiu, L.; Wang, C.; Lei, X.; Du, X.; Guo, Q.; Zhou, S.; Cui, P.; Hong, T.; Jiang, P.; Wang, J.*; Li, Y.*; Xia, J.* Biomaterial Sci. accepted.

2  “3D printed gelatin/hydroxyapatite scaffolds for stem cell chondrogenic differentiation and articular cartilage repair” Huang, J.; Huang, Z.; Liang, Y.; Yuan, W.; Bian, L.; Duan, L.; Rong, Z.; Xiong, J.*; Wang, D.*; Xia, J.* Biomaterials Sci. 2021, DOI: 10.1039/D0BM02103B

3  “Non-surgical osteoarthritis therapy, intra-articular drug delivery toward clinical applications”
Liang Yujie, Xia, J.* J. Drug Targeting 2021, 1-16 (review)

4  “Engineering exosomes for targeted drug delivery”
Liang, Y.; Duan, L.; Lu, J.; Xia, J.* Theranostics 2021, 11, 3183-3195 (review)

5  “Exosome-mediated delivery of gene vectors for gene therapy”
Duan, L.; Xu, L.; Xu, X.; Qin, Z.; Zhou, X.; Xiao, Y.; Liang, Y.*; Xia, J.* Nanoscale 2021, 13, 1387-1397. (Review)

6  “Exosome-mediated drug delivery for cell-free therapy of osteoarthritis”
Duan, L*.; Xu, X.; Xu, L.; Chen, H.; Li, X.; Alahdal, M.; Xiao, Y.; Liang, Y.*; Xia, J.* Curr. Med. Chem. 2020, DOI: 10.2174/0929867327666201118161232.

7  “Exosome-Mediated Delivery of Kartogenin for Chondrogenesis of Synovial Fluid-Derived Mesenchymal Stem Cells and Cartilage Regeneration” Xu, X.; Liang, Y.; Li, X.; Ouyang, K.; Wang, M.; Cao, T.; Li, W.; Liu, J.; Xiong, J.; Li, B.; Xia, J.*; Wang, D.*; Duan, L.* Biomaterials 2020, 269, 120539.

8 “Antibacterial photodynamic peptides for staphylococcal skin infection”
Lei, X.; Qiu, L.; Lan, M.; Du, X.; Zhou, S.; Cui, P.; Zheng, R.; Jiang, P.*; Wang, J.*; Xia, J.* Biomater. Sci. 2020, 8, 6695-6702.

9 “Synthetic Multienzyme Complexes Assembled on Virus-like Particles for Cascade Biosynthesis In Cellulo”
Wei, Q.; He, S.; Qu, J.; Xia, J.* Bioconjugate Chem. 2020, 31, 2413-2420.

10 “Bacteriophage-derived Endolysins to Target Gram-Negative Bacteria”
Lai, W. C. B.; Chen, X.; Ho, M. K. Y.; Xia, J.; Leung, S. S. Y. Int. J. Pharmaceutics 2020, 589, 119833

11 “Mesenchymal Stem Cell-Derived Exosomes for Treatment of Autism Spectrum Disorder”
Liang, Y.; Duan, L.; Xu, X.; Li, X.; Liu, M.; Chen, H.; Lu, J.*; Xia, J.* ACS Appl. Bio Mater. 2020, 3, 6384−6393.

12 “Chondrocyte-Targeted MicroRNA Delivery by Engineered Exosomes toward a Cell-Free Osteoarthritis Therapy”
Liang, Y.; Xu, X.; Li, X.; Xiong, J.; Li, B.; Duan, L.*; Wang, D.*; Xia, J.* ACS Appl. Mater. Interfaces 2020, 12, 36938–36947

13 “Host–guest protein assembly for affinity purification of methyl-lysine proteomes”
Li, L.; Liu, M.; Yue, L.; Wang, R.; Zhang, N.; Liang, Y.; Zhang, L.; Cheng, L.*; Xia, J.*; Wang, R.* Anal. Chem. 202092, 9322-9329.

14 “Phase-separated multienzyme biosynthesis”
Liu, M.; He, S.; Cheng, L.; Qu, J.; Xia, J.* Biomacromolecules, 2020, 21, 2391-2399.

15 “Safeguarding intestine cells against enteropathogenic Escherichia coli by intracellular protein reaction, a preventive antibacterial mechanism”
Qiu, J.; Nie, Y.; Zhao, Y.; Zhang, Y.; Li, L.; Wang, R.; Wang, M.; Chen, S.; Wang, J.*; Li, Y.Q.*; Xia, J.* Proc. Natl. Acad. Sci. U. S. A. 2020, 117, 5260-5268.

16 “On-Resin Passerini Reaction towards C-Terminal Photocaged Peptides”
So, W. H.; Xia, J.* Organic Lett. 2020, 22, 214-218.

17 “Self-Assembled Multi-Enzyme Nanostructures on Synthetic Protein Scaffolds”
Liu, Z.; Cao, S.; Liu, M.; Kang, W.; Xia, J.*. ACS Nano 2019, 13, 11343-11352.

18 “Modular enzyme assembly for enhanced cascade biocatalysis and metabolic flux”
Kang, W.; Ma, T.; Liu, M.; Qu, J.; Liu, Z.; Zhang, H.; Shi, B.; Fu, S.; Ma, J.; Lai, L.; He, S.; Qu, J.; Au, S. W-N.; Kang, B. H.; Lau, W. C. Y.; Deng, Z.; Xia, J.*, Liu, T.*. Nat. Commun. 2019, 10, 4248.

19 “Synthetic Multienzyme Complexes, Catalytic Nanomachineries for Cascade Biosynthesis In Vivo.”
Qu, J., Cao, S., Wei, Q., Zhang, H., Wang, R., Kang, W., Ma, T., Zhang, L., Liu, T., Au, W-N. S., Sun, F., Xia, J.* ACS Nano 2019, 13, 9895-9906.

20 “Magnetic enhancement of chondrogenic differentiation of mesenchymal stem cells”
Huang, J.; Liang, Y.; Huang, Z.; Zhao, P.; Liang, Q.; Liu, Y.; Duan, L.; Liu, W.; Zhu, F.; Bian, L.; Xia, J.*, Xiong, J.;* Wang, D.* ACS Biomaterials Science & Engineering, 2019, 5, 2200-2207. [Supplementary Cover].

21 “Site-selective lysine reactions guided by protein-peptide interaction”
Zhang, Y.; Liang, Y.; Huang, F.; Zhang, Y.; Li, X.; Xia, J.* Biochemistry 2019, 58, 1010-1018. 

22 “Affinity purification of methyllysine proteome by site-specific covalent conjugation”
Wang, R.; Huang, M.; Li, L.; Kaneko, T.; Voss, C.; Zhang, L.*; Xia, J.*; Li, S. S. C.* Anal. Chem. 2018, 90, 13876-13881. 

23 “Reverse binding mode of phosphotyrosine peptides with SH2 protein”
Wang, R.; Leung, P. Y. M.; Huang, F.; Tang, Q.; Kaneko, T.; Huang, M.; Li, Z.; Li, S. S. C.*; Wang, Y.*; Xia, J.* Biochemistry 2018, 57, 5257-5269.

24 “Syntenin-targeted peptide blocker inhibits progression of cancer cells”
Liu, J.; Qu, J.; Zhou, W.; Huang, Y.; Jia, L.; Huang, X.; Qian, Z.; Xia, J.*; Yu. Y.* Eur. J. Med. Chem. 2018, 154, 354-366. 

25 “Versatile site-selective protein reaction guided by WW domain–peptide motif interaction”
Liu, M.; Ji, Z.; Zhang, M.; Xia, J.* Bioconjugate Chem., 2017, 28, 2199-2205.

26 “Site-selective covalent reactions on proteinogenic amino acids”
So, W. H.; Zhang, Y.; Kang, W.; Wong, C. T. T.*; Sun, H.*; Xia, J.* Curr. Opin. Biotech. 2017, 48, 220–227  (Invited review).

27 “Targeted Covalent Inhibition of Grb2–Sos1 Interaction through Proximity-Induced Conjugation in Breast Cancer Cells” 
Yu, Y.; Nie, Y.; Feng, Q.; Qu, J.; Wang, R.; Bian, L.; Xia, J.* Mol. Pharmaceutics 2017, 14, 1548−1557. 

28 “Thiol-ether Stabilized DProline-LProline Induced b-Hairpin Peptide of Defensin Segment Increases its Anti-Candida Albicans Ability”
Zhao, B.; Yang, D.; Wong, J. H.; Wang, J.; Yin, C.; Zhu, Y.; Fan, S.; Ng, T. B.*; Xia, J*.; Li, Z.* Chembiochem 2016, 17, 1416 – 1420. 

29 “Affinity-guided protein conjugation: the trilogy of covalent protein labeling, assembly and inhibition”
Yu, Y.; Xia, J.* Sci. China Chem. 2016, 59, 1-8 (Invited review)

30 “PDZ-reactive peptide activates ephrin-B reverse signaling and inhibits neuronal chemotaxis”
Yu, Y.; Liu, M.; Ng, T. T.; Huang, F.; Nie, Y.; Wang, R.; Yao, Z-P.; Li, Z.; Xia, J.* ACS Chem. Biol. 2016, 11, 149-158.