Professor
Room 360 Science Centre
(852) 3943 6165
(852) 2603 5057
Education
1999 | B.Sc. | Nanjing University |
2002 | M.S. | Nanjing University |
2006 | Ph.D. | Stanford University |
Position
Since 2021.8 | Professor, Department of Chemistry, Professor (by courtesy), School of Life Sciences, The Chinese University of Hong Kong |
2015-2021 | Associate Professor (by courtesy), School of Life Sciences, The Chinese University of Hong Kong |
2015-2021 | Associate Professor, Department of Chemistry, The Chinese University of Hong Kong |
2009-2014 | Assistant Professor, The Chinese University of Hong Kong |
2007-2008 | Research Associate, Howard Hughes Medical Institute |
2007-2008 | Postdoctoral scholar, California Institute of Technology |
Research Interests
Chemical and synthetic biology
We are interested in the chemistry, biology, and engineering of proteins, and applying chemistry in biomedicine (Chem4BioMed) and synthetic biology (Chem4SynBio). Site-selective protein reactions Multienzyme complexes Regenerative medicine |
Recent Publications
For the complete publication list, click here
1 | Bao, Y.; Chen, H.; Xu, Z.; Gao, J.; Jiang, L.; Xia, J.* Photo-Responsive Phase-Separating Fluorescent Molecules for Intracellular Protein Delivery Angew. Chem. Int. Ed. 2023, DOI: 10.1002/anie.202307045 |
2 | Xu, L.†; Xu, X.†; Liang, Y.; Wen, C.; Ouyang, K.; Huang, J.; Xiao, Y.; Deng, X.; Xia, J.*; Duan, L.* Osteoclast-Targeted Delivery of Anti-miRNA Oligonucleotides by Red Blood Cell Extracellular Vesicles. Journal of Controlled Release 2023, 358, 259-272. |
3 | Liang, Y.†; Iqbal, Z.†; Lu, J.; Wang, J.; Zhang, H.; Chen, X.; Duan, L.*; Xia, J.* Cell-Derived Nanovesicle-Mediated Drug Delivery to the Brain: Principles and Strategies for Vesicle Engineering. Molecular Therapy 2023, 31, 1207-1224. |
4 | Liu, M.; Wang, Y.; Jiang, H.; Han, Y.; Xia, J.* Synthetic Multienzyme Assemblies for Natural Product Biosynthesis. ChemBioChem 2023, 24, e202200518. |
5 | Yuan, D.†; Zhang, Y.†; Lim, K. H.; Leung, S. K. P.; Yang, X.; Liang, Y.; Lau, W. C. Y.; Chow, K. T.*; Xia, J.* Site-Selective Lysine Acetylation of Human Immunoglobulin G for Immunoliposomes and Bispecific Antibody Complexes. J. Am. Chem. Soc. 2022,144, 18494-18503. (†, equal contribution) |
6 | Wang, Y.†; Liu, M.†; Wei, Q.; Wu, W.; He, Y.; Gao, J.; Zhou, R.; Jiang, L.; Qu, J.; Xia, J.* Phase-Separated Multienzyme Compartmentalization for Terpene Biosynthesis in a Prokaryote Angew. Chem. Int. Ed. 2022, e202203909. |
7 | Wei, Q.†; Wang, Y.†; Liu, Z.†; Liu, M.; Cao, S.; Jiang, H.; Xia, J.* Multienzyme Assembly on Caveolar Membranes In Cellulo ACS Catalysis 2022, 12, 8372-8379. (†, equal contribution) |
8 | Liang, Y.; Xu, X.; Xu, L.; Ouyang, K.; Zhang, H.; Duan, L.; Xia, J.* Chondrocyte-Specific Genome Editing Enabled by Hybrid Exosomes for Osteoarthritis Treatment Theranostics 2022, 12, 4866-4878. |
9 | So, W. H.†; Bao, Y.†; Chen, X.; Xia, J.* On-Resin Ugi Reaction for C-Terminally Modified and Head-to-Tail Cyclized Antibacterial Peptides Organic Letters 2021, 23, 8277-8281. (†, equal contribution) |
10 | Duan, L.; Ouyang, K.; Wang, J.; Xu, L.; Xu, X.; Wen, C.; Xie, Y.; Liang, Y.*; Xia, J.* Exosomes as Targeted Delivery Platform of CRISPR/Cas9 for Therapeutic Genome Editing ChemBioChem 2021, 22, 3360-3368. |
11 | Wang, C.; Hong, T.; Cui, P.; Wang, J.*; Xia, J.* Antimicrobial peptides towards clinical application: delivery and formulation Advanced Drug Delivery Review, 2021, 175, 113818. |
12 | Liang, Y.; Duan, L.; Lu, J.; Xia, J.* Engineering exosomes for targeted drug delivery Theranostics 2021, 11, 3183-3195. |
13 | Qiu, J.; Nie, Y.; Zhao, Y.; Zhang, Y.; Li, L.; Wang, R.; Wang, M.; Chen, S.; Wang, J.*; Li, Y.Q.*; Xia, J.* Safeguarding intestine cells against enteropathogenic Escherichia coli by intracellular protein reaction, a preventive antibacterial mechanism Proc. Natl. Acad. Sci. U. S. A. 2020, 117, 5260-5268. |
14 | Xu, X.; Liang, Y.; Li, X.; Ouyang, K.; Wang, M.; Cao, T.; Li, W.; Liu, J.; Xiong, J.; Li, B.; Xia, J.*; Wang, D.*; Duan, L.* Exosome-Mediated Delivery of Kartogenin for Chondrogenesis of Synovial Fluid-Derived Mesenchymal Stem Cells and Cartilage Regeneration Biomaterials 2020, 269, 120539. |
15 | Liang, Y.; Xu, X.; Li, X.; Xiong, J.; Li, B.; Duan, L.*; Wang, D.*; Xia, J.* Chondrocyte-Targeted MicroRNA Delivery by Engineered Exosomes toward a Cell-Free Osteoarthritis Therapy ACS Appl. Mater. Interfaces 2020, 12, 36938–36947 |
16 | So, W. H.; Xia, J.* On-Resin Passerini Reaction towards C-Terminal Photocaged Peptides Organic Lett. 2020, 22, 214-218. |
17 | Kang, W.; Ma, T.; Liu, M.; Qu, J.; Liu, Z.; Zhang, H.; Shi, B.; Fu, S.; Ma, J.; Lai, L.; He, S.; Qu, J.; Au, S. W-N.; Kang, B. H.; Lau, W. C. Y.; Deng, Z.; Xia, J.*, Liu, T.*. Modular enzyme assembly for enhanced cascade biocatalysis and metabolic flux Nat. Commun. 2019, 10, 4248. |
18 | Liu, Z.; Cao, S.; Liu, M.; Kang, W.; Xia, J.* Self-Assembled Multi-Enzyme Nanostructures on Synthetic Protein Scaffolds ACS Nano 2019, 13, 11343-11352. |
19 | Qu, J., Cao, S., Wei, Q., Zhang, H., Wang, R., Kang, W., Ma, T., Zhang, L., Liu, T., Au, W-N. S., Sun, F., Xia, J.* Synthetic Multienzyme Complexes, Catalytic Nanomachineries for Cascade Biosynthesis In Vivo. ACS Nano 2019, 13, 9895-9906. |
Recent Grants
1. | ITF TCFS, 1/8/2022 – 31/7/2024, PI Title: Engineering Exosomes for Tissue Regeneration and Osteoarthritis Treatment ITC GHP/074/20SZ: HK$1,350,000 Shenzhen Kaimao Biotechnology Co. Ltd.: HK$150,000 PH-ITF: PiH/283/22 HK$804,000 PH-ITF: PiH/284/22 HK$804,000 |
2. | RGC GRF 22/23, 14306222, 1/1/2023– 31/12/2025, HK$ 870,000, PI Title: Chemoenzymatic tyrosine reactions for covalent protein labeling and exosome tracking |
3. | RGC GRF 21/22, 14304921, 1/1/2022 – 31/12/2024, HK$ 624,615, PI Title: Phase-separated multienzyme biosynthesis in vitro and in cellulo |
4. | RGC GRF 20/21, 14304320, 1/1/2021 – 31/12/2023, HK$ 666,512, PI Title: Site-Specific Acetylation of Immunoglobulin G, for Covalent Construction of Therapeutic Antibody Conjugates |
5. | Research Sustainability of Major RGC Funding Schemes (RSFS), 4930971, CUHK Faculty of Medicine. 3/6/2019 – 2/12/2020. HK$ 625,000. PI Title: Stem Cell-Based Chemical Biology Approach to Cartilage Repair |
6. | ITF TCFS, 1/2/2020 – 31/1/2022, PI (total 3,931,244.81 HKD) Title: Efficient Enzymatic Production of Diacylglycerol ITC GHP/060/18GD: HK$ 1,620,000 Shenzhen WWHS Ltd.: HK$180,000 PH-ITF: PiH/395/19: HK$ 801,782.75 PH-ITF: PiH/396/19: HK$ 801,782.75 InP/459/19, ITC: HK$ 527,679.31 PH-ITF: PiH/321/20: HK$539,360 PH-ITF: InP/334/20: HK$ 299,961.29. |
7. | NSFC/RGC 18/19, N_CUHK422/18, 1/1/2019-31/12/2022, HK$ 1,120,056, PI Title: Hybrid Antimicrobial Peptide-Nylon-3 Polymers to Treat Infection in the Brain |
8. | Collaborative grant from industry, TJ1914536, 1/3/2020 – 28/2/2025, HK$ 1,500,000, PI Title: Recombinant collagen biomaterials Grant source: Jiangsu Unicollagen Biomedicine Co., Ltd. |