Professor XIA, Jiang(夏江教授)


location    Room 360 Science Centre

Phone No.    (852) 3943 6165

Fax No.     (852) 2603 5057


Research Group Webpage    Prof. Xia’s Research Group





1999 B.Sc. Nanjing University
2002 M.S. Nanjing University
2006 Ph.D. Stanford University



Since 2021.8 Professor, Department of Chemistry, 
Professor (by courtesy), School of Life Sciences, The Chinese University of Hong Kong
2015-2021 Associate Professor (by courtesy), School of Life Sciences, The Chinese University of Hong Kong
2015-2021 Associate Professor, Department of Chemistry, The Chinese University of Hong Kong
2009-2014 Assistant Professor, The Chinese University of Hong Kong
2007-2008 Research Associate, Howard Hughes Medical Institute
2007-2008 Postdoctoral scholar, California Institute of Technology


Research Interests

Chemical and synthetic biology

We are interested in the chemistry, biology, and engineering of proteins, and applying chemistry in biomedicine (Chem4BioMed) and synthetic biology (Chem4SynBio).

Site-selective protein reactions
Residue-specific (cysteine, tyrosine, and lysine) reactions of proteins, enzymes, and antibodies in vitro and in cells

Multienzyme complexes
Multienzyme complexes, synthetic metabolon, and synthetic organelles; regulation of metabolic flux in prokaryotic and eukaryotic cells for better biosynthesis of carotenoids, artemisinin, cannabinoids, or amorphadiene, in vitro and in cells

Regenerative medicine
Engineering exosomes, extracellular vesicles, and cells for targeted therapy of cartilage and skin regeneration, peptides or enzymes against bacterial infection, and cancer therapies in cells and in vivo


Recent Publications

For the complete publication list, click here

1 Bao, Y.; Chen, H.; Xu, Z.; Gao, J.; Jiang, L.; Xia, J.*
Photo-Responsive Phase-Separating Fluorescent Molecules for Intracellular Protein Delivery
Angew. Chem. Int. Ed. 2023, DOI: 10.1002/anie.202307045
2 Xu, L.†; Xu, X.†; Liang, Y.; Wen, C.; Ouyang, K.; Huang, J.; Xiao, Y.; Deng, X.; Xia, J.*; Duan, L.*
Osteoclast-Targeted Delivery of Anti-miRNA Oligonucleotides by Red Blood Cell Extracellular Vesicles.
Journal of Controlled Release 2023, 358, 259-272.
3 Liang, Y.†; Iqbal, Z.†; Lu, J.; Wang, J.; Zhang, H.; Chen, X.; Duan, L.*; Xia, J.*
Cell-Derived Nanovesicle-Mediated Drug Delivery to the Brain: Principles and Strategies for Vesicle Engineering.
Molecular Therapy 2023, 31, 1207-1224.
4 Liu, M.; Wang, Y.; Jiang, H.; Han, Y.; Xia, J.*
Synthetic Multienzyme Assemblies for Natural Product Biosynthesis.
ChemBioChem 2023, 24, e202200518.
5 Yuan, D.†; Zhang, Y.†; Lim, K. H.; Leung, S. K. P.; Yang, X.; Liang, Y.; Lau, W. C. Y.; Chow, K. T.*; Xia, J.*
Site-Selective Lysine Acetylation of Human Immunoglobulin G for Immunoliposomes and Bispecific Antibody Complexes.
J. Am. Chem. Soc. 2022,144, 18494-18503. (†, equal contribution)
6 Wang, Y.†; Liu, M.†; Wei, Q.; Wu, W.; He, Y.; Gao, J.; Zhou, R.; Jiang, L.; Qu, J.; Xia, J.*
Phase-Separated Multienzyme Compartmentalization for Terpene Biosynthesis in a Prokaryote
Angew. Chem. Int. Ed. 2022, e202203909.
7 Wei, Q.†; Wang, Y.†; Liu, Z.†; Liu, M.; Cao, S.; Jiang, H.; Xia, J.*
Multienzyme Assembly on Caveolar Membranes In Cellulo
ACS Catalysis 2022, 12, 8372-8379. (†, equal contribution)
8 Liang, Y.; Xu, X.; Xu, L.; Ouyang, K.; Zhang, H.; Duan, L.; Xia, J.*
Chondrocyte-Specific Genome Editing Enabled by Hybrid Exosomes for Osteoarthritis Treatment
Theranostics 2022, 12, 4866-4878.
9 So, W. H.†; Bao, Y.†; Chen, X.; Xia, J.*  
On-Resin Ugi Reaction for C-Terminally Modified and Head-to-Tail Cyclized Antibacterial Peptides
Organic Letters 2021, 23, 8277-8281. (†, equal contribution)
10 Duan, L.; Ouyang, K.; Wang, J.; Xu, L.; Xu, X.; Wen, C.; Xie, Y.; Liang, Y.*; Xia, J.*
Exosomes as Targeted Delivery Platform of CRISPR/Cas9 for Therapeutic Genome Editing
2021, 22, 3360-3368. 
11 Wang, C.; Hong, T.; Cui, P.; Wang, J.*; Xia, J.* 
Antimicrobial peptides towards clinical application: delivery and formulation
Advanced Drug Delivery Review2021, 175, 113818. 
12 Liang, Y.; Duan, L.; Lu, J.; Xia, J.
Engineering exosomes for targeted drug delivery
Theranostics 202111, 3183-3195. 
13 Qiu, J.; Nie, Y.; Zhao, Y.; Zhang, Y.; Li, L.; Wang, R.; Wang, M.; Chen, S.; Wang, J.*; Li, Y.Q.*; Xia, J.* 
Safeguarding intestine cells against enteropathogenic Escherichia coli by intracellular protein reaction, a preventive antibacterial mechanism
Proc. Natl. Acad. Sci. U. S. A. 2020117, 5260-5268.
14 Xu, X.; Liang, Y.; Li, X.; Ouyang, K.; Wang, M.; Cao, T.; Li, W.; Liu, J.; Xiong, J.; Li, B.; Xia, J.*; Wang, D.*; Duan, L.* 
Exosome-Mediated Delivery of Kartogenin for Chondrogenesis of Synovial Fluid-Derived Mesenchymal Stem Cells and Cartilage Regeneration
Biomaterials 2020269, 120539.
15 Liang, Y.; Xu, X.; Li, X.; Xiong, J.; Li, B.; Duan, L.*; Wang, D.*; Xia, J.* 
Chondrocyte-Targeted MicroRNA Delivery by Engineered Exosomes toward a Cell-Free Osteoarthritis Therapy
ACS Appl. Mater. Interfaces 202012, 36938–36947
16 So, W. H.; Xia, J.* 
On-Resin Passerini Reaction towards C-Terminal Photocaged Peptides
Organic Lett. 202022, 214-218.
17 Kang, W.; Ma, T.; Liu, M.; Qu, J.; Liu, Z.; Zhang, H.; Shi, B.; Fu, S.; Ma, J.; Lai, L.; He, S.; Qu, J.; Au, S. W-N.; Kang, B. H.; Lau, W. C. Y.; Deng, Z.; Xia, J.*, Liu, T.*. 
Modular enzyme assembly for enhanced cascade biocatalysis and metabolic flux
Nat. Commun. 201910, 4248.
18 Liu, Z.; Cao, S.; Liu, M.; Kang, W.; Xia, J.*
Self-Assembled Multi-Enzyme Nanostructures on Synthetic Protein Scaffolds
ACS Nano 201913, 11343-11352.
19 Qu, J., Cao, S., Wei, Q., Zhang, H., Wang, R., Kang, W., Ma, T., Zhang, L., Liu, T., Au, W-N. S., Sun, F., Xia, J.* 
Synthetic Multienzyme Complexes, Catalytic Nanomachineries for Cascade Biosynthesis In Vivo.
ACS Nano 201913, 9895-9906.


Recent Grants

1. ITF TCFS, 1/8/2022 – 31/7/2024, PI
     Title: Engineering Exosomes for Tissue Regeneration and Osteoarthritis Treatment
           ITC GHP/074/20SZ: HK$1,350,000 

           Shenzhen Kaimao Biotechnology Co. Ltd.: HK$150,000
           PH-ITF: PiH/283/22 HK$804,000
           PH-ITF: PiH/284/22 HK$804,000
2. RGC GRF 22/23, 14306222, 1/1/2023– 31/12/2025, HK$ 870,000, PI
     Title: Chemoenzymatic tyrosine reactions for covalent protein labeling and exosome tracking
3. RGC GRF 21/22, 14304921, 1/1/2022 – 31/12/2024, HK$ 624,615, PI
     Title: Phase-separated multienzyme biosynthesis in vitro and in cellulo
4. RGC GRF 20/21, 14304320, 1/1/2021 – 31/12/2023, HK$ 666,512, PI
     Title: Site-Specific Acetylation of Immunoglobulin G, for Covalent Construction of Therapeutic Antibody Conjugates
5. Research Sustainability of Major RGC Funding Schemes (RSFS), 4930971, CUHK Faculty of Medicine. 3/6/2019 – 2/12/2020. HK$ 625,000. PI
     Title: Stem Cell-Based Chemical Biology Approach to Cartilage Repair
6. ITF TCFS, 1/2/2020 – 31/1/2022, PI (total 3,931,244.81 HKD)
     Title: Efficient Enzymatic Production of Diacylglycerol
           ITC GHP/060/18GD: HK$ 1,620,000 

           Shenzhen WWHS Ltd.: HK$180,000
           PH-ITF: PiH/395/19: HK$ 801,782.75
           PH-ITF: PiH/396/19: HK$ 801,782.75
           InP/459/19, ITC: HK$ 527,679.31
           PH-ITF: PiH/321/20: HK$539,360
           PH-ITF: InP/334/20: HK$ 299,961.29.
7. NSFC/RGC 18/19, N_CUHK422/18, 1/1/2019-31/12/2022, HK$ 1,120,056, PI
     Title: Hybrid Antimicrobial Peptide-Nylon-3 Polymers to Treat Infection in the Brain
8. Collaborative grant from industry, TJ1914536, 1/3/2020 – 28/2/2025, HK$ 1,500,000, PI
     Title: Recombinant collagen biomaterials
     Grant source: Jiangsu Unicollagen Biomedicine Co., Ltd.