Professor Jiang XIA(夏江教授)

Associate Professorppl---Jx

location Room 360 Science Centre
Phone No. (852) 3943 6165
Fax No. (852) 2603 5057









1999 B.Sc. Nanjing University
2002 M.S. Nanjing University
2006 Ph.D. Stanford University



Since 2015.4 Associate Professor (by courtesy), School of Life Sciences, The Chinese University of Hong Kong
Since 2014.12 Associate Professor, Department of Chemistry, The Chinese University of Hong Kong
2008.12-2014.12 Assistant Professor, The Chinese University of Hong Kong
2007-2008 Research Associate, Howard Hughes Medical Institute
2007-2008 Postdoctoral scholar, California Institute of Technology


Research Interests

Chemical biology and synthetic biology

— with a focus on subcellular structures, such as organelles and protein coacervates, and their biocatalytic and biomedical applications.

1. Protein reactions: site-selective protein reactions (cysteine, tyrosine to lysine reactions); reactions of proteins, enzymes, antibodies to organelles
2. Protein assembly: multienzyme complexes, synthetic metabolon and synthetic organelles
3. Protein biomaterials: cartilage and skin regeneration and anti-infection


Selected Publications

1 “Engineering exosomes for targeted drug delivery”
Liang, Y.; Duan, L.; Lu, J.; Xia, J.* Theranostics 2020 doi:10.7150/thno.52570 (review)
2 “Exosome-mediated delivery of gene vectors for gene therapy”
Duan, L.; Xu, L.; Xu, X.; Qin, Z.; Zhou, X.; Xiao, Y.; Liang, Y.*; Xia, J.* Nanoscale 2020 DOI: 10.1039/D0NR07622H. (Review)
3 “Exosome-mediated drug delivery for cell-free therapy of osteoarthritis”
Duan, L*.; Xu, X.; Xu, L.; Chen, H.; Li, X.; Alahdal, M.; Xiao, Y.; Liang, Y.*; Xia, J.* Curr. Med. Chem. 2020, DOI: 10.2174/0929867327666201118161232.
4 “Exosome-Mediated Delivery of Kartogenin for Chondrogenesis of Synovial Fluid-Derived Mesenchymal Stem Cells and Cartilage Regeneration”
Xu, X.; Liang, Y.; Li, X.; Ouyang, K.; Wang, M.; Cao, T.; Li, W.; Liu, J.; Xiong, J.; Li, B.; Xia, J.*; Wang, D.*; Duan, L.* Biomaterials, 2020,
5 “Antibacterial photodynamic peptides for staphylococcal skin infection”
Lei, X.; Qiu, L.; Lan, M.; Du, X.; Zhou, S.; Cui, P.; Zheng, R.; Jiang, P.*; Wang, J.*; Xia, J.* Biomater. Sci. 2020 DOI: 10.1039/D0BM01467B
6 “Synthetic Multienzyme Complexes Assembled on Virus-like Particles for Cascade Biosynthesis In Cellulo
Wei, Q.; He, S.; Qu, J.; Xia, J.* Bioconjugate Chem. 2020 doi: 10.1021/acs.bioconjchem.0c00476
7 “Bacteriophage-derived Endolysins to Target Gram-Negative Bacteria”
Lai, W. C. B.; Chen, X.; Ho, M. K. Y.; Xia, J.; Leung, S. S. Y. Int. J. Pharmaceutics 2020, 589, 119833
8 “Mesenchymal Stem Cell − Derived Exosomes for Treatment of Autism Spectrum Disorder”
Liang, Y.; Duan, L.; Xu, X.; Li, X.; Liu, M.; Chen, H.; Lu, J.*; Xia, J.* ACS Appl. Bio Mater. 2020, 3, 6384−6393.
9 “Chondrocyte-Targeted MicroRNA Delivery by Engineered Exosomes toward a Cell-Free Osteoarthritis Therapy”
Liang, Y.; Xu, X.; Li, X.; Xiong, J.; Li, B.; Duan, L.*; Wang, D.*; Xia, J.* ACS Appl. Mater. Interfaces 2020, 12, 36938–36947
10 “Host–guest protein assembly for affinity purification of methyl-lysine proteomes”
Li, L.; Liu, M.; Yue, L.; Wang, R.; Zhang, N.; Liang, Y.; Zhang, L.; Cheng, L.*; Xia, J.*; Wang, R.* Anal. Chem. 2020. (Link)
11 “Phase-separated multienzyme biosynthesis”
Liu, M.; He, S.; Cheng, L.; Qu, J.; Xia, J.* Biomacromolecules, 2020, (Link)
12 “Safeguarding intestine cells against enteropathogenic Escherichia coli by intracellular protein reaction, a preventive antibacterial mechanism”
Qiu, J.; Nie, Y.; Zhao, Y.; Zhang, Y.; Li, L.; Wang, R.; Wang, M.; Chen, S.; Wang, J.*; Li, Y.Q.*; Xia, J.* Proc. Natl. Acad. Sci. U. S. A. 2020, 117, 5260-5268. (Link)
13 “On-Resin Passerini Reaction towards C-Terminal Photocaged Peptides”
So, W. H.; Xia, J.* Organic Lett. 2020, 22, 214-218. (Link)
14 “Self-Assembled Multi-Enzyme Nanostructures on Synthetic Protein Scaffolds”
Liu, Z.; Cao, S.; Liu, M.; Kang, W.; Xia, J.*. ACS Nano 2019, 13, 11343-11352.
15 “Modular enzyme assembly for enhanced cascade biocatalysis and metabolic flux”
Kang, W.; Ma, T.; Liu, M.; Qu, J.; Liu, Z.; Zhang, H.; Shi, B.; Fu, S.; Ma, J.; Lai, L.; He, S.; Qu, J.; Au, S. W-N.; Kang, B. H.; Lau, W. C. Y.; Deng, Z.; Xia, J.*, Liu, T.*. Nat. Commun. 2019, 10, 4248. (Link)
16 “Synthetic Multienzyme Complexes, Catalytic Nanomachineries for Cascade Biosynthesis In Vivo.”
Qu, J., Cao, S., Wei, Q., Zhang, H., Wang, R., Kang, W., Ma, T., Zhang, L., Liu, T., Au, W-N. S., Sun, F., Xia, J.*. ACS Nano 2019, 13, 9895-9906. (Link)
17 “Magnetic enhancement of chondrogenic differentiation of mesenchymal stem cells”
Huang, J.; Liang, Y.; Huang, Z.; Zhao, P.; Liang, Q.; Liu, Y.; Duan, L.; Liu, W.; Zhu, F.; Bian, L.; Xia, J.*, Xiong, J.;* Wang, D.* ACS Biomaterials Science & Engineering, 2019, 5, 2200-2207. (Link) [Featured on Supplementary Cover].
18 “Site-selective lysine reactions guided by protein-peptide interaction”
Zhang, Y.; Liang, Y.; Huang, F.; Zhang, Y.; Li, X.; Xia, J.* Biochemistry. 2019, 58, 1010-1018. (Link)
19 “Affinity purification of methyllysine proteome by site-specific covalent conjugation”
Wang, R.; Huang, M.; Li, L.; Kaneko, T.; Voss, C.; Zhang, L.*; Xia, J.*; Li, S. S. C.* Anal. Chem. 2018, 90, 13876-13881. (Link)
20 “Reverse binding mode of phosphotyrosine peptides with SH2 protein”
Wang, R.; Leung, P. Y. M.; Huang, F.; Tang, Q.; Kaneko, T.; Huang, M.; Li, Z.; Li, S. S. C.*; Wang, Y.*; Xia, J.* Biochemistry 2018, 57, 5257-5269. (Link)
21 “Syntenin-targeted peptide blocker inhibits progression of cancer cells”
Liu, J.; Qu, J.; Zhou, W.; Huang, Y.; Jia, L.; Huang, X.; Qian, Z.; Xia, J.*; Yu. Y.* Eur. J. Med. Chem. 2018, 154, 354-366. (Link)
22 “A proximity-induced covalent fluorescent probe for selective detection of bromodomain 4”
Feng, L.; Chhabra, M.; So, W. H.; Zhu, Q.; Xia, J.*; Sun, H.* Chin. Chem. Letters, 2018, 29, 1147-1150. (Link)
23 “Peptide photocaging: a brief account of the chemistry and biological applications”
So, W. H.; Wong, C. T. T.; Xia, J.* Chin. Chem. Letters, 2018, 29, 1058-1062 (Invited review). (Link)
24 “Versatile site-selective protein reaction guided by WW domain–peptide motif interaction”
Liu, M.; Ji, Z.; Zhang, M.; Xia, J.* Bioconjugate Chem., 2017, 28, 2199-2205. (Link)
25 “Site-selective covalent reactions on proteinogenic amino acids”
So, W. H.; Zhang, Y.; Kang, W.; Wong, C. T. T.*; Sun, H.*; Xia, J.* Curr. Opin. Biotech. 2017, 48, 220–227 (Link) (Invited review).
26 “Targeted Covalent Inhibition of Grb2–Sos1 Interaction through Proximity-Induced Conjugation in Breast Cancer Cells”
Yu, Y.; Nie, Y.; Feng, Q.; Qu, J.; Wang, R.; Bian, L.; Xia, J.* Mol. Pharmaceutics, 2017, 14, 1548−1557. (Link)
27 “Thiol-ether Stabilized DProline-LProline Induced b-Hairpin Peptide of Defensin Segment Increases its Anti-Candida Albicans Ability”
Zhao, B.; Yang, D.; Wong, J. H.; Wang, J.; Yin, C.; Zhu, Y.; Fan, S.; Ng, T. B.*; Xia, J*.; Li, Z.* Chembiochem, 2016, 17, 1416 – 1420. (Link)
28 “Affinity-guided protein conjugation: the trilogy of covalent protein labeling, assembly and inhibition”
Yu, Y.; Xia, J.* Sci. China Chem. 2016, 59, 1-8 (Invited review) (Link)
29 “PDZ-reactive peptide activates ephrin-B reverse signaling and inhibits neuronal chemotaxis”
Yu, Y.; Liu, M.; Ng, T. T.; Huang, F.; Nie, Y.; Wang, R.; Yao, Z-P.; Li, Z.; Xia, J.* ACS Chem. Biol. 2016, 11, 149-158. (Link)
30 “Site selective Azo coupling for peptide cyclization and affinity labeling of an SH3 protein.”
Huang, F.; Nie, Y.; Ye, F.; Zhang, M.; Xia, J.* Bioconjugate Chem. 2015, 26, 1613-1622.
31 “Antiviral activities of whey proteins”
Ng, T. B.; Cheung, R. C.; Wong, J. H.; Wang, Y.; Ip, D. T.; Wan, D. C.; Xia, J. Appl. Microbiol. Biotechnol. 2015, 99, 6997-7008. (Link)