Professor TAM, Dick Yan Karen (譚廸茵教授)

Research Assistant ProfessorProf. Dick Yan TAM

location Room G82 Science Centre

Phone No. (852) 3943 1326


 0000- 0002-0490-4125







2015-2020 Ph.D. City University of Hong Kong
2009-2012 B.Sc. The University of Hong Kong



Since 2021 Research Assistant Professor, The Chinese University of Hong Kong


Research Interests

My research will focus on
1. functionalizing biocompatible nanomaterials with theranostic agents for diagnosis and therapy
2. developing nanodevices for bioanalytical, computing or other biological applications


Honours and Awards

2019 Best Poster Award (Analytical & Environmental Chemistry), 2019, The 26th Symposium on Chemistry Postgraduate Research in Hong Kong
2017-2019 Outstanding Academic Performance Award for Research Degree Students (local UGC-funded students), 2017-2019, SGS of City University of Hong Kong


Representative Publications

1. Tam, D. Y.,‡ Ho, J. W-T.,‡ Chan, M. S., Lau, C. H., Chang, T. J. H., Leung, H. M., Liu, L. S., Wang ,F., Chan, L. L. H., Tin, C., & Lo, P. K., Penetrating the Blood–Brain Barrier by Self-Assembled 3D DNA Nanocages as Drug Delivery Vehicles for Brain Cancer Therapy, 20 May 2020 In: ACS Applied Materials & Interfaces. 12, 26, p. 28928-28940
2. Tam, D. Y., Zhuang, X., Wong, S. W. & Lo, P. K., Photoresponsive Self-Assembled DNA Nanomaterials: Design, Working Principles, and Applications, 26 Jun 2019, In: Small. 15, 26, 1805481.
3. Tam, D. Y., Leung, H. M., Chan, M. S. & Lo, P. K., G-Quadruplex-Mediated Molecular Switching of Self-Assembled 3D DNA Nanocages, 1 Oct 2017, In: ChemNanoMat. 3, 10, p. 750-754
4. Tam, D. Y., Dai, Z., Chan, M. S., Liu, L. S., Cheung, M. C., Bolze, F., Tin, C. & Lo, P. K., A Reversible DNA Logic Gate Platform Operated by One- and Two-Photon Excitations, 4 Jan 2016, In: Angewandte Chemie – International Edition. 55, 1, p. 164-168
5. Tam, D. Y. & Lo, P. K., Multifunctional DNA nanomaterials for biomedical applications, 19 Mar 2015, In: Journal of Nanomaterials. 2015, 765492
6. Wang, F., Liu, L.S., Li, P., Leung, H.M, Tam, D.Y. & Lo, P. K., Biologically stable threose nucleic acid-based probes for real-time microRNA detection and imaging in living cells, 8 Mar 2022, In: Molecular Therapy – Nucleic Acids. 27, 787-796.
7. Leung, H. M., Lau, C. H., Ho, J. W-T., Chan, M. S., Chang, T. J. H., Law, L. H., Wang, F., Tam, D. Y., Liu, L. S., Chan, K. W. Y., Tin, C., & Lo, P. K. Targeted brain tumor imaging by using discrete biopolymer-coated nanodiamonds across the blood-brain barrier, 7 Feb 2021 In: Nanoscale. 13, 5, p. 3184-3193.
8. Wang, F., Liu, L. S., Lau, C. H., Han Chang, T. J., Tam, D. Y., Leung, H. M., Tin, C. & Lo, P. K, Synthetic α-L-Threose Nucleic Acids Targeting BcL-2 Show Gene Silencing and in Vivo Antitumor Activity for Cancer Therapy, 23 Oct 2019, In: ACS Applied Materials and Interfaces. 11, 42, p. 38510−38518
9. Liu, C., Zhou, B., Geng, Y., Tam, D. Y., Feng, R., Miao, H., Xu, N., Shi, X., You, Y., Hong, Y., Zhong, B., Lo, P.K., Kuryavyi, V. & Zhu, G., A chair-type G-quadruplex structure formed by a human telomeric variant DNA in K+ solution, 7 Jan 2019, In: Chemical Science. 10, 1, p. 218-226
10. Liu, L. S., Leung, H. M., Tam, D. Y., Lo, T. W., Wong, S. W. & Lo, P. K., α- L -Threose Nucleic Acids as Biocompatible Antisense Oligonucleotides for Suppressing Gene Expression in Living Cells, 21 Mar 2018, In: ACS Applied Materials and Interfaces. 10, 11, p. 9736-9743
11. Wang, Z., Tam, D. Y., Susha, A. S., Chan, M. S., Kershaw, S. V., Lo, P. K. & Rogach, A. L., Aggregation-free DNA nanocage/Quantum Dot complexes based on electrostatic adsorption, 20 Apr 2016, In: Colloids and Surfaces A: Physicochemical and Engineering Aspects. 495, p. 62-67
12. Chan, M. S., Tam, D. Y., Dai, Z., Liu, L. S., Ho, J. W., Chan, M. L., Xu, D., Wong, M.S., Tin, C. & Lo, P.K., Mitochondrial Delivery of Therapeutic Agents by Amphiphilic DNA Nanocarriers, 10 Feb 2016, In: Small. 12, 6, p. 770-781
13. Dai, Z., Tam, D. Y., Xu, H., Chan, M. S., Liu, L. S., Bolze, F., Sun, X. H. & Lo, P. K., Conformational Change of Self-Assembled DNA Nanotubes Induced by Two-Photon Excitation, 2 Sep 2015, In: Small. 11, 33, p. 4090-4096
14. Chan, M. S., Xu, D., Guo, L., Tam, D. Y., Liu, L. S., Chen, Y., Wong, M. S. & Lo, P. K., Cyanine fluorophores for cellular protection against ROS in stimulated macrophages and two-photon ROS detection, 14 Jul 2015, In: Organic and Biomolecular Chemistry. 13, 26, p. 7307-7312
15. Guo, L., Chan, M. S., Xu, D., Tam, D. Y., Bolze, F., Lo, P. K. & Wong, M. S., Indole-based Cyanine as a Nuclear RNA-Selective Two-Photon Fluorescent Probe for Live Cell Imaging 15 May 2015, In: ACS Chemical Biology. 10, 5, p. 1171-1175


Major Grant

CUHK, Direct grant (2021/2022). G-quadruplex-based horseradish peroxidase mimicking DNAzyme activating chemiluminescence-mediated photodynamic therapy, PI, 2021-2022




LO, P. K. P., LIU, L. S., & TAM, D. Y. (Accepted/In press). Methods And Compositions for Synthesis of Two-photon Cleavable Phosphoramidite Molecules for Oligonucleotide Conjugation.